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July 14, 2020 02:14 PM
The molecular architecture of Tight Junctions has gradually been unraveled in recent years, providing the basis for Barriology, the science of the barrier in multicellular organisms.
Epithelia and endothelia separate different tissue compartments and protect multicellular organisms from the outside world. This requires the formation of tight junctions, selective gates that control paracellular diffusion of ions and solutes. 
In the liver, a claudin-2–based paracellular channel supplies Na+ and water to the perivenous region of the liver lobule to generate directional bile flow from the center to the periphery of the lobule.