Robert Ryley Parrish

Research Interests

The Parrish lab is addressing key questions related to epilepsy and seizure disorders. We are particularly interested in mechanisms of endogenous inhibitory restraint and spontaneous seizure termination. Understanding how the brain prevents the spread of seizures across cortical tissue and how seizures terminate on their own likely hold key insights into novel approaches to prevent seizures. We have a keen interest in a phenomenon known as a cortical spreading depression, represented as a slow wave of glia and neuronal depolarization followed by a period of neuronal suppression. These events often follow seizures in the brain and are likely the same events that are termed post-ictal depressions, observed on EEGs in the clinic. Interestingly, cortical spreading depressions are also believed to be the cellular correlate of migraines. Using optogenetic tools and electrophysiology, we have discovered a novel and exciting way to induce these cortical spreading depressions, which will allow our lab to gain new insight into these events and understand their relationship to both seizure termination and migraines.

Education

• Ph. D., Neuroscience , University of Alabama at Birmingham (2014)
• B.S., Physical Science , Auburn University Montgomery (2007)

Honors and Awards

• 1st Place Platform Presentation, UK-Ireland International League Against Epilepsy (2016 - 2016)
• 1st Place Poster Prize, Northeast Epilepsy Research Meeting (2015 - 2015)
• 2nd Place Poster Presentation, University of Alabama at Birmingham Neurobiology Retreat (2012 - 2012)
• 1st Place Talk on Original Research, 85th Annual Meeting of the Alabama Academy of Sciences (2008 - 2008)
• Chancellor's Scholar, Auburn University Montgomery (2007 - 2007)
• Physical Science Student of the Year, Auburn University Montgomery (2007 - 2007)

Memberships

• American Epilepsy Society (2023 - Present)
• The American Physiological Society (2022 - Present)
• Society for Neuroscience (2008 - Present)

Professional Citizenship

• Other, Frontiers (2022 - Present)

Courses Taught

Show Previous Years

Publications

Alec Vaughan Laura McMeekin Kutter Hine Isaac Stubbs Neela Codadu Simon Cockell Jonathon T Hill Rita Cowell Andrew Trevelyan Robert Ryley Parrish Samuel Goodchild Noah Shuart Aaron Williams Wenlei Ye Robert Parrish JP Johnson Robert Parrish Andrew J Trevelyan Robert Parrish C Mackenzie-Gray-Scott T Jackson-Taylor A Grundmann F McLeod N K Codadu A Călin H Alfonsa R C Wykes J Voipio A J Trevelyan R T Graham Robert Parrish L Alberio E Johnson L Owens A J Trevelyan F Mulroe W H Lin C Mackenzie-Gray Scott N Aourz Y N Fan G Coutts Robert Parrish I Smolders A Trevelyan R C Wykes S Allan S Freeman R A Baines S Thouta M G Waldbrook S Lin A Mahadevan J Mezeyova M Soriano P Versi S J Goodchild R Ryley Parrish Andrew Trevelyan Robert Graham R Ryley Parrish Neela Codadu A Mahadevan N K Codadu R Ryley Parrish C Mackenzie-Gray Scott Robert Parrish D Walsh C Racca R M Cowell A J Trevelyan C A Papasavvas Robert Parrish A J Trevelyan R J Burman J S Selfe J H Lee M van den Berg A Calin N K Codadu R Wright S E Newey Robert Parrish Ana Clair Katz J M Wilmshurst C J Akerman A J Trevelyan J V Raimondo N K Codadu R T Graham R J Burman R T Jackson-Taylor J V Raimondo A J Trevelyan R Ryley Parrish C A Schevon S Tobochnik T Eissa E Merricks Brian DaCosta Gill Robert Parrish L M Bateman G M McKhann, Jr R G Emerson A J Trevelyan Robert Parrish N K Codadu C Mackenzie-Gray Scott A J Trevelyan R G Sánchez Robert Parrish M Rich W M Webb R M Lockhart K Nakao L Ianov S C Buckingham D R Broadwater Alexander E Jenkins N C de Lanerolle M Cunningham T Eid K Riley F D Lubin N K Codadu Robert Parrish A J Trevelyan Robert Parrish N K Codadu C Racca A J Trevelyan R J Burman R Ryley Parrish Robert Parrish J Grady N K Codadu C Racca A J Trevelyan Robert Parrish J Grady N K Codadu A J Trevelyan C Racca Robert Parrish A J Trevelyan M R Penner Robert Parrish L T Hoang T L Roth F D Lubin C A Barnes Robert Parrish S C Buckingham K L Mascia J J Johnson M M Matyjasik R M Lockhart F D Lubin R Ryley Parrish A J Albertson S C Buckingham J J Hablitz K L Mascia W Davis Haselden F D Lubin Robert Parrish J J Day F D Lubin F D Lubin S Gupta Robert Parrish N M Grissom R L Davis Robert Parrish S Gupta F D Lubin C A Miller C F Gavin J A White Robert Parrish A Honasoge C R Yancey I M Rivera M D Rubio G Rumbaugh J D Sweatt

Presentations