Research in the Hill Lab
The Hill Lab studies molecular genetics by combining bench biology, high-throughput sequencing, and bioinformatics. Our research focuses on how genetic and epigenetic information shapes development, disease, and biodiversity.
Heart Development and the Genetics of Congenital Heart Defects
The vertebrate heart begins as a simple linear tube that loops and remodels to form the mature heart. Disruptions to this process can lead to congenital heart defects, one of the most common types of birth defects.
Our lab uses zebrafish as a model system to study the genes and regulatory pathways that guide heart development. By combining gene expression analysis, bioinformatics, and bench biology, we aim to understand normal heart development and how genetic changes contribute to congenital heart disease.
Developing Epigenetic and Genetic Diagnostics
Although the DNA sequence is largely stable throughout life, chemical modifications that regulate DNA function, such as DNA methylation, vary across cell types, age, environmental exposures, and disease states. These epigenetic patterns can provide valuable information about health and disease.
In collaboration with the Tim Jenkins Lab, we are using emerging sequencing technologies to measure genetic and epigenetic variation and develop diagnostic approaches. Current projects focus on neurodegeneration, male fertility, heart disease, and other conditions where molecular signatures may improve detection, prediction, or treatment.
Sequencing and Assembling Genomes from Brazil
Brazil is home to remarkable biodiversity, including many endangered and understudied species that lack genomic resources. In collaboration with Emilio Lanna at the Universidade Federal da Bahia, we are sequencing and assembling genomes from a wide range of Brazilian species.
Using long-read sequencing, genome assembly, annotation, and comparative genomics, we generate resources that can support studies of evolution, adaptation, population diversity, and conservation.
DR. JONATHON HILL
Cell Biology and Physiology Professor
3018 LSB
801-422-8970
jhill@byu.edu
Curriculum Vitae