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College of Life Sciences Cell Biology and Physiology
Mizrachi Lab
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Publications

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Publications

  1. Overexpression of a constitutively active death receptor induces apoptosis in cancer cells. Peterson K., Palmer B., Christensen C., Bailey S., Mizrachi D. (Archives of Molecular Biology and Genetics 2022, in press)
  2. A biologic that prevents metastasis and engages CAR technology. Mendoza C. and Mizrachi D. (Biomedicines 2022)
  3. Calcium regulates the interplay between tight junction and epithelial adherens junction at the plasma membrane. Mendoza C., Nagidi S.H., Collett K., Mckell J. and Mizrachi D. FEBS Letters 2021 (Dec 9. doi: 10.1002/1873-3468.14252. Online ahead of print. PMID: 34882783)
  4. Chimeric Claudins: A New Tool to Study Tight Junction Structure and Function. Taylor A, Warner M, Mendoza C, Memmott C, LeCheminant T, Bailey S, Christensen C, Keller J, Suli A, Mizrachi D. Int J Mol Sci. 2021 May 6;22(9):4947
  5. Molecular Characterization of the Extracellular Domain of Human Junctional Adhesion Proteins. Mendoza C, Nagidi SH, Mizrachi D. Int J Mol Sci. 2021 Mar 27;22(7):3482
  6. Expression of cell-adhesion molecules in E. coli: a high-throughput method to identify paracellular modulators. Rollins J, Worthington T, Hooke E, Hobson J, Wengler J, Hope S, and Mizrachi D. 2021 BioRxiv doi: https://doi.org/10.1101/2021.04.08.439041 
  7. VDAC1 and the TSPO: Expression, interaction and associated functions in health and disease states. Shoshan-Barmatz, V., Pittala, S. and Mizrachi, D., Int. J. Mol. Sci. 20(13): 3348, 2019.
  8. Identification and kinetics characterization of a wax ester hydrolase from a feather-degrading actinomycete. Barcus, M., Mizrachi, D., and Lei, X.G., bioRxiv, August, 2017.
  9. A water-soluble DsbB variant that catalyzes disulfide-bond formation in vivo. Dario Mizrachi, D., Robinson, M.-P., Ren, G., Ke, N., Berkmen, M., and DeLisa, M.P. Nature Chemical Biology 13:1022–1028, 2017.
  10. The Voltage-dependent Anion Channel 1 Mediates Amyloid β Toxicity and Represents a Potential Target for Alzheimer Disease Therapy. Smilansky, A., Dangoor, L., Nakdimon, I., Ben-Hail, D., Mizrachi, D., Shoshan-Barmatz, V.., J. Biol. Chem. 290(52):30670- 83, 2015.
  11. Evolutionary comparisons predict that dimerization of human cytochrome P450 aromatase increases its enzymatic activity and efficiency. Conley, A., Corbin, J., Mizrachi, D., Holien, J., Rodgers, R., Parker, M., and Martin, L., J. of Steroid Biochemistry and Molecular Biology 154:294-301, 2015.
  12. Making water-soluble integral membrane proteins using an engineered amphipathic protein fusion. Mizrachi, D., Chen, Y., Liu, J., Peng, H.-M., Ke, A., Pollack, L., Auchus, R., Turner, R.J., and DeLisa, M.P., Nature Communications 6:6826, 2015.
  13. At the crossroads between mitochondrial metabolite transport and apoptosis: VDAC1 as an emerging cancer drug target. Shoshan-Barmatz, V., Shteinfer, A., Ben Hail, D., Arif, T., and Mizrachi, D., Chapter 16 in: Stress Response Pathways in Cancer, Springer Science, 2015. (DOI 10.1007/978-94-017-9421-3)
  14. Beyond the cytoplasm of Escherichia coli: localizing recombinant proteins where you want them. Boock, JT, Waraho-Zhmayev, D, Mizrachi, D, and DeLisa, MP. Methods Mol Biol 1258:79-97, 2015.
  15. Progenitor Cell Line (hPheo1) Derived from a Human Pheochromocytoma Tumor. Ghayee, H.K., Bhagwandin, V.J., Stastny, V., Click, A., Ding, L.-H., Mizrachi, D., Zou, Y.S.,  Chari, R., Lam, W.L., Bachoo, R.M., Smith, A.L., Story, M.D., Sidhu, S., Robinson, B.G., Nwariaku, F.E., Gazdar, A.F., Auchus, R.J., Shay, J.W., PLoS One 8(6), 2013.
  16. Oligomerization of the mitochondrial protein VDAC1: From structure to function and cancer therapy. Shoshan-Barmatz, V., Mizrachi, D., Keinan, N., In: “Oligomerization in Health and Disease,” Prog. Mol. Biol. Transl. Sci. 117:303-34, 2013. 
  17. VDAC1: from structure to cancer therapy. Shoshan-Barmatz, V. and Mizrachi, D., Front Oncol. 2:164, 2012.
  18. VDAC1 (voltage-dependent anion channel 1). Atlas of Genetics and Cytogenetics in Oncology and Haematology, Shoshan-Barmatz, V. and Mizrachi, D., http://atlasgeneticsoncology.org/index.html, 2012.
  19. Effects of Psychosocial Stress on the Pattern of Salivary Protein Release. Trueba, A.F.,  Vogel, P., Mizrachi, D., Auchus, R. and Ritz, T., Physiol. Behav. 105(3):841-849, 2011
  20. Biochemical characterization of human AGPAT isoforms 1 and 2 and their inability to rescue hepatic steatosis in Agpat2-/- lipodystrophic mice. Agarwal, A.K., Sukumaran, S., Cortés, V.A., Tunison, K., Mizrachi, D., Gerard, R., Luby-Phelps, K., Horton, J.D., and Garg, A., J. Biol. Chem. 286(43):37676-91, 2011.
  21. Why Human Cytochrome P450c21 is a Progesterone 21- Hydroxylase. Mizrachi, D., Wang, Z., Sharma, K, Gupta, M.K., Xu, K., Dwyer, C.R., and Auchus R.J., Biochemistry 50(19):3968-74, 2011.
  22. PSMB8, a gene encoding a catalytic subunit of the proteasome, is mutated in patients with joint contractures, muscle atrophy, microcytic anemia and panniculitis-induced lipodystrophy (JMP) syndrome. Agarwal, A.K., Xing, C., DeMartino, G.N., Mizrachi, D., Dolores Hernandez, M., Sousa, A.B., Martínez de Villarreal, L., dos Santos, H.G., Garg, A., Am J Hum Genet. 87(6):866-72, 2010.
  23. PLUNC is a secreted product of airway epithelia and neutrophil granules with surfactant activity. Bartlett, J., Gakhar, L., Mizrachi, D., Ramaswamy, S., McCray, P., PLoS One. 5(2):e9098, 2010.
  24. Biochemical factors governing the steady-state estrone/estradiol ratios catalyzed by human 17beta-hydroxysteroid dehydrogenases types 1 and 2 in HEK-293 cells. Sherbet, D.P., Guryev, O.L., Papari-Zareei, M., Mizrachi, D., Rambally, S., Akbar, S., Auchus, R.J., Endocrinology 150(9): 4154-62, 2009.
  25. Androgens, estrogens, and hydroxysteroid dehydrogenases. Mizrachi, D., Auchus, R., Mol. Cell Endocrinol. 301(1-2):37-42, 2009.
  26. The Role of a Non-Conserved Residue in the Second Intracellular Loop in Conferring Different Basal Constitutive Activities of the Human Lutropin and Thyrotropin Receptors. Feng, X., Mueller, T.*, Mizrachi, D.*, Fanelli, F., and Segaloff, D.L., Endocrinology. 149(4):1705, 2008. (*contributed equally)
  27. Structure-function relationships of gonadotropin action. Segaloff, D.L. and Mizrachi, D., In: Updates in Infertility Treatment 2004 (Filicori, M., ed.), Medimond, 17-28, 2005.
  28. The formation of a salt bridge between helices 3 and 6 is responsible for the constitutive activity and lack of hormone responsiveness of the naturally occurring L457R mutation of the human lutropin receptor. Zhang, M., Mizrachi, D., Fanelli, F., and Segaloff, D.L., J. Biol. Chem. 280(28):26169-76, 2005.
  29. Intracellularly Located Misfolded Glycoprotein Hormone Receptors Associate with Different Chaperone Proteins than their Cognate Wild-Type Receptors. Mizrachi, D., and Segaloff, D.L., Mol. Endocrinol. 18(7):1768-77, 2004.
  30. Thyroid-Stimulating Hormone/Luteinizing Hormone/Follicle-Stimulating Hormone Receptors. Segaloff, D.L., Mizrachi, D. and Ascoli, M., In: Encyclopedia of Biological Chemistry (Lennarz, W.J and Lane, M.D., eds.) Elsevier Science, 4:180-186, 2004.
  31. Chimeras of the rat and human follitropin receptors (FSHR) identify residues that permit or suppress TM6 mutation-induced constitutive activation of the hFSHR via rearrangements of hydrophobic interactions between helices 6 and 7. Tao, Y.-X., Mizrachi, D., and Segaloff, D.L., Mol. Endocrinol. 16(8):1881-92, 2002.
  32. Expression of functional luteinizing hormone (LH) receptor and its messenger ribonucleic acid in bovine endometrium: LH augmentation of cAMP and inositol phosphate in vitro and human chorionic gonadotropin (hCG) augmentation of peripheral prostaglandin in vivo. Shemesh, M., Mizrachi, D., Gurevich, M., Shore, L.S., Reed, J., Chang, S.-M.T., Thatcher, W.W., and Fields, M.J., Reprod. Biol. 1:15-34, 2001.
  33. Functional importance of bovine myometrial and vascular LH receptors and cervical FSH receptors.  Shemesh, M., Mizrachi, D., Gurevich, M., Stram, Y., Shore, L.S., Fields, M.J., Seminars in Reproductive Endocrinology 19:87-96, 2001.
  34. Direct involvement of LH in uterine function. Shemesh, M., Mizrachi, D., Gurevich, M., Stram, Y., Shore, L.S., and Fields, M.J., Reproduction in Domestic Animals 35:163-166, 2000.
  35. Follicle stimulating hormone receptor and its messenger RNA are present in the bovine cervix and can regulate cervical prostanoid. Mizrachi, D. and Shemesh, M., Biol Reprod. 61:776-784, 1999.
  36. Expression of functional luteinizing hormone receptor and its mRNA in bovine cervix: LH augmentation of cAMP, phosphate inositol and cyclooxeganase. Mizrachi, D. and Shemesh, M., Mol. Cell. Endocrinol. 157:191-200, 1999.
  37. Expression of functional luteinizing hormone receptor and its mRNA in bovine uterine veins; Luteinizing hormone induction of cyclooxygenase and augmentation of prostaglandin production in bovine uterine veins. Shemesh, M., Gurevich, M., Mizrachi, D., Dombrovski, L., Fields, M.J., and Shore, L.S., Endocrinology 138:4844-4851, 1997.

Posters and Presentations

  1. Biophysical Society, “High-throughput technology to identify absorption enhancers.” Mizrachi, D., New Orleans, oral presentation, 2017.
  2. ASBMB, “Engineering Tight Junctions in E. coli.” Rollins, Worthington and Mizrachi, D., San Diego, Poster, 2018.
  3. Biophysical Society, “A water-soluble DsbB variant that catalyzes disulfide-bond formation in vivo.” Dario Mizrachi, Matthew DeLisa, 2018 (Oral presentation)
  4. Biophysical Society, “High-throughput technology to identify absorption enhancers.” Rollins, Worthington and Mizrachi, D., Baltimore, Poster, 2019.
  5. ASBMB, “Chimeric claudins to study the role of tight junction in development.” Taylor, Keller and Mizrachi, D., San Diego, Poster, 2020.
  6. ASCB, “Junctional Adhesion Molecules in cell-adhesion” Online, Poster 2020.
  7. UCUR 2019, Cardiac tissue engineering, stem cells. Valencia Amores S. and Mizrachi, D.
  8.   CURA 2019. Bacterial method for the study of claudins. Jay Rollins and Dario Mizrachi.
  9. CURA 2020. Extracellular Matrix for cardiac tissue engineering. Sebastian Valencia and Dario Mizrachi
  10. CURA 2021, “Role of Integrins and Junctional Adhesion Molecules in hemostasis” Nagidi, Mendoza and Mizrachi
  11. Optimization of Growth and Harvest of SNAP-25 using E. coli. Jacob McKell, Kjetil Collett, Christopher Mendoza, Dario Mizrachi, Jade Bookwalter, Ryan Knapp, Liam Eccles, Kaden Taylor, and Dixon J. Woodbury
  12. ASBMB 2022, “Tight Junction membrane proteins in neural tube defects.” Allen, Stark and Mizrachi
  13. UCUR 2022, “Junctional Adhesion Molecules in chicken development.” Beckett N. and Mizrachi D.