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Peer-Reviewed Publications

Undergraduate co-authors are italicized

  1. Poornejad N, Momtahan N, Salehi ASM,Scott D, Fronk C, Roeder BL, Reynolds PR, Bundy B, and Cook AD. 2018. Corrigendum: Efficient Decellularization of whole porcine kidneys improves reseeded cell behavior. Biomed Mater. doi: 10.1088/1748-605X/aadd22.
  2. Hirschi KM, Chapman S, Hall P, Ostergar A, Winden DR, Reynolds PR, and Arroyo JA. Gas6 induces invasion and reduces inflammatory cytokines in oral squamous cell carcinoma cells. J Oral Pathol Med. 2018 Jun 1. doi: 10.1111/jop.12738.
  3. Lewis JB, Bodine JS, Gassman JR, Munoz SA, Milner DC, Dunaway DM, Egbert KM,Monson TD, Broberg DS, Arroyo JA, and Reynolds PR. 2018. Transgenic up-regulation of Claudin-6 decreases fine diesel particulate matter (DPM)-induced pulmonary inflammation. Environ Sci and Poll, 25(18): 18179-88.
  4. Lewis JB, Jimenez FR, Merrell BJ,Kimbler B, Arroyo JA, and Reynolds PR. 2018. The expression profile of Claudin family members in the developing mouse lung and expression alterations resulting from exposure to secondhand smoke (SHS). Exp Lung Res, 11:1-12. doi: 10.1080/01902148.2017.140984.
  5. Chapman S, Mick M, Hall P,Mejia C, Sue S, Wase BA, Nguyen MA, Whisenant EC, Wilcox SH, Winden DR, Reynolds PR, and Arroyo JA. 2018. Cigarette smoke extract induces oral squamous cell carcinoma cell invasion in a receptor for advanced glycation end-product-dependent manner. Eur J Oral Sci, doi: 10.1111/eos.12395.
  6. Lewis JB, Mejia C, Jordan C, Monson TD, Bodine JS, Dunaway TM, Egbert KM, Lewis AL, Wright TJ, Ogden KC, Broberg DS, Hall PD, Nelson SM, Hirschi KM, Reynolds PR and Arroyo JA. 2017. Inhibition of the receptor for advanced glycation end-products (RAGE) protects from secondhand smoke (SHS)-induced intrauterine growth restriction (IUGR) in mice. Cell Tissue Res, 2017 Sep 26. doi: 10.1007/s00441-017-2691-z.
  7. Kumar V, Fleming T, Terjung S, Gorzelanny C, Gebhardt C, Agrawal R, Mall MA, Ranzinger J, Zeier M, Madhusudhan T, Ranjan S, Iserman B, Liesz A, Deshpande D, Häring HU, Biswas SK, Reynolds PR, Hammes HP, Peperkok R, Angel P, Herzig S and Nawroth PP. 2017. Homeostatic nuclear RAGE-ATM interaction is essential for efficient DNA repair. Nuc Acid Res, 2017 Aug 9. doi: 10.1093/nar/gkx705.
  8. Poornejad N, Buckmiller E, Schaumann L, Wang H, Wisco J, Roeder B, Reynolds P, and Cook A. 2017. Re-epithelialization of whole porcine kidneys with renal epithelial cells. J Tissue Eng 8:1-22, DOI 10.1177/2041731417718809.
  9. Taylor OJ, Thatcher MO, Carr ST, Gibbs J, Trumbull AM, Harrison ME, Winden DR, Pearson MJ, Tippetts TS, Holland WL, Reynolds PR, and Bikman BT. 2017. High-mobility Group Box 1 disrupts metabolic function with cigarette smoke exposure in a ceramide-dependent manner. Int J Mol Sci. 18(5):1099; doi: 10.3390/ijms18051099.
  10. Napa K., Baeder AC, Witt JE, Rayburn ST, Miller MG, Dallon BW, Gibbs JL, Wilcox SH, Winden DR, Reynolds PR, and Bikman BT. 2017. LPS from P. Gingivalis negatively alters gingival cell mitochondrial bioenergetics. Int J Dentistry2017: 2697210.
  11. Monson T,Wright T, Galan HL, Reynolds PR, and Arroyo JA. 2017. Caspase dependent and independent mechanisms of apoptosis across gestation in a sheep model of placenta insufficiency and intrauterine growth restriction. Apoptosis 22(5): 710-718.
  12. Lewis JB, Hirschi KM, Arroyo JA, Bikman BT, Kooyman DT, and Reynolds PR. 2017. Plausible roles for RAGE in conditions exacerbated by direct and indirect (secondhand) smoke exposure. Int J Mol Sci. 18(3):652; doi:10.3390/ijms18030652.
  13. Sanders NT, Dutson DJ, Durrant JW, Lewis JB, Wilcox SH, Winden DR, Arroyo JA, Bikman BT, and Reynolds PR. 2017. Cigarette Smoke Extract (CSE) Induces RAGE-Mediated Inflammation in the Ca-9-22 Gingival Carcinoma Epithelial Cell Line. Archives of Oral Biology80:95-100.
  14. Black CS, Creapeau PK, Sheffiend ID, Macdonald JR, Wooton DJ, Maek M, Eggett DL, Reynolds PR, and Kooyman DL. 2017. Identification of the tidemark line of calcification in osteoarthritic cartilage using a stain for alkaline phosphatase. J Arthritis6:230. Doi:10.4172/2167-7921.1000230.
  15. Jimenez FR, Lewis JB, Belgique ST, Milner DC, Lewis AL, Dunaway TM, Egbert KM, Winden DR, Arroyo JA, and Reynolds PR. 2016. Cigarette smoke and decreased oxygen tension inhibit pulmonary Claudin-6 expression. Exp Lung Res, 42(8-10):440-452.
  16. Lewis JB, Milner DC, Lewis AL, Dunawy TM, Egbert KM, Albright SC, Merrell BJ, Monson TD, Broberg DS, Gassman JR, Thomas DB, Arroyo JA and Reynolds PR. 2016. Up-regulation of Claudin-6 in the distal lung impacts secondhand smoke-induced inflammation. Int J Environ Res Public Health, 13:1018; doi:10.3390/ijerph13101018.
  17. Mejia C, Lewis J, Jordan C, Mejia J, Ogden C, Monson T, Winden D, Reynolds PR, and Arroyo JA. 2016. Decreased activation of placental mTOR family members is associated with the induction of intrauterine growth restriction (IUGR) by secondhand smoke (SHS) in the mouse. Cell Tissue Res, 9 Sept 2016, DOI: 10.1007/s00441-016-2496-5.
  18. Poornejad N, Schaumann LB, Buckmiller EM, Momtahan N, Gassman JR, Ma HH, Roeder BL, Reynolds PR and Cook AD. The impact of decelluralization agents on renal tissue extracellular matrix. J Biomater Appl, 0885328216656099.
  19. Chavez EM, Mecham DK, Black JW, Graf JW, Wilhelm SK, Anderson KM, Mitchell JA, Macdonald JR, Hollis WR, Eggett DL, Reynolds PR, and Kooyman DL. Malocclusion Model of Temporomandibular Joint Osteoarthritis in Mice with and Without Receptor For Advanced Glycation End Products. Archives of Oral Biology, 69:47-62.
  20. Long E, Motwani R, Reece D, Pettit N, Hepworth J, Wong P, Reynolds PR, and Seegmiller RE. 2016. The role of TGF-b1 in osteoarthritis of the temporomandibular joint in two genetic mouse models. Arch Oral Biol 67:68-73.
  21. Poornejad N, Momtahan N, Salehi ASM, Scott D, Fronk C, Roeder BL, Reynolds PR, Bundy B, and Cook AD. 2016. Efficient decellularization of whole procine kidneys improves reseeded behavior. Biomed Materials 11(2):025003.
  22. Baeder AC, Napa K, Richardson ST, Taylor OJ, Anderson SG, Wilcox SH, Winden DR, Reynolds PR, and Bikman BT. 2016. Oral Gingival Cell Cigarette Smoke Exposure Induces Muscle Cell Metabolic Disruption. Int J Dentistry 2016: 2763160.
  23. Alexander KL, Mejia CA, Jordan C, Nelson MB, Howell BM, Jones CM, Reynolds PR, and Arroyo JA. 2015. Differential Receptor for Advanced Glycation End-Products (RAGE) Expression in Preeclamptic, Intrauterine Growth Restricted, and Gestational Diabetic Placentas. Am J Reprod Immunol, 75(2):172-180.
  24. Kimball R, Wayment M, Merrill D, Wahlquist T, Reynolds PR, and Arroyo JA. 2015. Hypoxia reduces placental mTOR activation in a hypoxia-induced model of intrauterine growth restriction (IUGR). Physiol Rep 3(12):e12651.
  25. Poornejad N, Nielson J, Morris R, Gassman J, Reynolds PR, Roeder BL, and Cook AD. 2015. Comparison of four decontamination treatments on porcine renal dECM structure, composition, and support of human rena; cortical tubular epithelium cells. J Biomater Appl, doi:10.1177/0885328215615760.
  26. Siebert M, Wilhelm SK, Kartchner JZ, Mecham D, Reynolds PR, and Kooyman DL. 2015. Effect of pharmacological blocking of TLR4 on osteoarthritis in mice. J Arthritis: 164. Doi:10.4172/2167-7921.1000164.
  27. Olsen DS, Goar WA, Nichols BA, Bailey KT, Christensen SL, Merriam KR, Reynolds PR, Wilson E, Weber KS, and Bridgewater LC. 2015. Targeted mutation of nuclear bone morphogenetic protein 2 (nBMPR2) impairs secondary immune response in a mouse model. BioMed Res Int, vol. 2015, Article ID 975789. doi:10.1155/2015/975789.
  28. Momtahan N, Poornejad N, Struk JA, Castleton AA, Herrod BJ, Vance BR, Eatough JP, Roeder BL, Reynolds PR, and Cook AD. 2015. Automation of pressure control improves whole porcine heart decellularization. T Tissue Engineering C, DOI: 10.1089/ten.tec.2014.0709.
  29. Jimenez FR, Belgique ST, Lewis JB, Albright SA, Jones CM, Howell BM, Mika AP, Jergensen TR, Gassman JR, Morris RJ, Arroyo JA, and Reynolds PR. 2015. Conditional pulmonary over-expression of Claudin-6 (Cldn6) during embryogenesis delays lung morphogenesis. Int J Dev Biol, doi: 10.1387/ijdb.150086pr.
  30. Nelson MB, Swensen AC, Winden DR, Bodine JS, Bikman BT, and Reynolds PR. 2015. Cardiomyocyte mitochondrial respiration is reduced by receptor for advanced glycation end-products (RAGE) signaling in a ceramide-dependent manner. AJP: Heart and Circulation Physiology 309:H63-H69.
  31. Poornejad N, Frost TS, Scott DR, Elton BB, Reynolds PR, Roeder BL, and Cook AD. 2015. Freezing/thawing without cryoprotectant damages native but not decellularized porcine renal tissue. Organogenesis in press.
  32. Tippetts TS, Winden DR, Swensen AC, Nelson MB, Thatcher MO, Saito RR, Condie TB, Simmons KJ, Judd AM, Reynolds PR, Bikman BT. 2014. Cigarette smoke increases cardiomyocyte ceramide accumulation and inhibits mitochondrial respiration. BMC Cardiovasc Disord., 2014 Nov 22; 14:165.
  33. Bodine BG, Bennion BG, Leatham E, Jimenez FR, Wright AJ, Jergensen ZR, Erickson CJ, Jones CM, Johnson JP, Knapp SM, and Reynolds PR 2014. Conditionally induced RAGE expression by proximal airway epithelial cells in transgenic mice causes lung inflammation. Respir Res, 15(1):133.
  34. Winden DR, Barton DB, Betteridge BC, Bodine JS, Jones CM, Rogers GD, Chavarria M, Wright AJ, Jergensen ZR, Jimenez FR, and Reynolds PR 2014. Antenatal exposure of maternal secondhand smoke (SHS) increases fetal lung expression of RAGE and induces RAGE-mediated pulmonary inflammation. Respir Res, 15(1):129.
  35. Thatcher MO, Tippetts TS, Nelson MB, Swensen AC, Winden DR, Hansen ME, Anderson MC, Johnson IE, Porter JP, Prince JT, Reynolds PR, Bikman BT. 2014. Ceramides mediate cigarette smoke-induced metabolic disruption in mice. Am J Physiol Endocrinol Metab., 2014 Sep 30, Epub ahead of print.
  36. Wood TT, Winden DR, Marlor DR, Wright AJ, Jones CM, Chavarria M, Rogers GD, Reynolds PR. 2014. Acute Secondhand Smoke-Induced Pulmonary Inflammation is Diminished in RAGE Knock out Mice. Am J Physiol Lung Cell Mol Physiol. 2014 Sep 26. Epub ahead of print.
  37. Jimenez F.R., Lewis B.L., Belgique S.T., Wood T.T., and Reynolds P.R. 2014. Developmental lung expression and transcriptional regulation of Claudin-6 by TTF-1, Gata-6, and FoxA2. Respir Res, 15(1):70.
  38. Barton D.B., Betteridge B.C., Earley T.D., Curtis C.S., Robinson A.B., and Reynolds P.R. 2014. Primary alveolar macrophages exposed to diesel particulate matter increase RAGE expression and activate RAGE signaling. Cell Tissue Res, 25 May 2014, Epub ahead of print.
  39. Winden D.R., Ferguson N.T., Bukey B.R., Geyer A.J., Wright A.J., Jergensen Z.R., Robinson A.B., Stogsdill J.R., and Reynolds P.R. 2013. Conditional over-expression of RAGE by embryonic alveolar epithelium compromises the respiratory membrane and impairs endothelial cell differentiation. Respir Res 14(1):108.
  40. Larkin D.J, Kartchner J.Z., Doxey A.S., Hollis W.R., Rees J.L., Wilhelm S.K., Draper C.S., Peterson D.M., Jackson G.G., Ingersoll C., Haynie S.S., Chavez E., Reynolds P.R., Kooyman D.L. 2013. Inflammatory markers associated with osteoarthritis after destabilization surgery in young mice with and without Receptor for Advanced Glycation End-Products (RAGE). Frontiers in Integ Physiol 4: 121. doi: 10.3389/fphys.2013.00121.
  41. Stogsdill M.P., Stogsdill J.A., Bodine B.G., Fredrickson A.C., Sefcik T.L., Wood T.A., Kasteler S.K., and Reynolds P.R. 2013. Conditional RAGE over expression in the adult murine lung causes airspace enlargement and induces inflammation. Am J Resp Cell Mol Biol 49(1):128-134.
  42. Ricks M.L., Farrell J.T., Falk D.J., Holt D.W., Rees M., Carr J., Williams T., Nichols B.A., Bridgewater L.C., Reynolds P.R., Kooyman D.L., and Seegmiller R.E. 2013. Osteoarthritis in temporomandibular joint of Col2a1 mutant mice. Advances in Oral Biology 58(9):1092-9.
  43. Robinson A.B., Stogsdill J.A., Lewis J.P., Wood T.A., and Reynolds P.R. 2012. RAGE and tobacco smoke: Insights into modeling Chronic Obstructive Pulmonary Disease. Frontiers in Resp Physiol 3:301. doi: 10.3389/fphys.2012.00301.
  44. Robinson A.B., Dickson, K.D., Bennion B.G., and Reynolds P.R. 2012. RAGE signaling by alveolar macrophages influences tobacco smoke-induced inflammation. AJP: Lung Cell Mol Physiol 302(11):L1192-9.
  45. Stogsdill J.A., Stogsdill M.P., Porter J.L., Hancock J.M., Robinson A.B., and Reynolds P.R. 2011. Embryonic over-expression of RAGE by alveolar epithelium induces an imbalance between proliferation and apoptosis. Am J Resp Cell Mol Biol. 47(1):60-6.
  46. Reynolds P.R., Stogsdill J.A., Stogsdill M.P., and Heimann N.B. 2011. Up-Regulation of RAGE by Alveolar Epithelium Influences Cytodifferentiation and Causes Severe Lung Hypoplasia. Am J Resp Cell Mol Biol 45(6): 1195-202.
  47. Bukey B.R., Geyer A.J., and Porter J.L. and Reynolds P.R. 2011. Immunohistochemical detection and regulation of alpha 5 nicotinic acetylcholine receptor (nAChR) subunits by FoxA2 during mouse lung organogenesis. Respir Res 12(1):82.
  48. Reynolds P.R., Allison C.H., and Willnauer C.P. 2010. TTF-1 Regulates Alpha 5 Nicotinic Acetylcholine Receptor (nAChR) Subunits in Proximal and Distal Lung Epithelium. Respir Res 11:175.
  49. Reynolds P.R., Wasley K.M., and Allison C.H. 2010. Diesel Particulate Matter Induces RAGE Expression in Pulmonary Epithelium and RAGE Signaling Influences NF-kB-Mediated Inflammation. Environ Health Per 119(3):332-9.
  50. Reynolds P.R., Kasteler S.D., Schmitt R.E. and Hoidal J.R. 2010. RAGE Signals Through Ras During Tobacco Smoke-Induced Pulmonary Inflammation. Am J Resp Cell Mol Biol 45(2):411-8.
  51. Rao N.V., Argyle B., Xu Z., Reynolds P.R., Walenga J.M., Prechel M., Prestwich G.D., Hoidal J.R., and Kennedy T.P. 2010. Low Anticoagulant Heparin Targets Multiple Sites in Inflammation, Suppresses Heparin-Induced Thrombocytopenia and Inhibits Interaction of RAGE with its Disparate Ligands. Am J Physiol Cell Physiol 299(1):C97-110.
  52. Reynolds P.R., Kasteler S.D., Sturrock A., Sanders K. Kennedy T.P. and Hoidal J.R. 2009. RAGE Targeting Protects Against Hyperoxia-Induced Lung Injury in Mice. Am J Resp Cell Mol Biol 42(5):545-51.
  53. Reynolds P.R., Kasteller S., Cosio M.G., Sturrock A., Huecksteadt T.P. and Hoidal J.R. 2008. RAGE: Developmental Expression and Positive Feedback Regulation by Egr-1 During Cigarette Smoke Exposure in Pulmonary Epithelial Cells. AJP: Lung Cell Mol Physiol 294(6):L1094-101.
  54. Reynolds P.R. and J.R. Hoidal. 2006. Cigarette Smoke-Induced Egr-1 Upregulates Pro-Inflammatory Cytokines in Pulmonary Epithelial Cells. Am J Resp Cell Mol Biol 35(3):314-9.
  55. Reynolds P.R. and J.R. Hoidal. 2005. Temporal-Spatial Expression and Transcriptional Regulation of a7 Nicotinic Acetylcholine Receptor (nAChR) by TTF-1 and Egr-1 During Murine Lung Development. J Biol Chem. 280(37):32548-54.
  56. Mukherjee T.P., Reynolds P.R and Hoidal J.R. 2005. Differential Effect of Estrogen Receptor Alpha and Beta Agonists on the Receptor for Advanced Glycation End Product Expression in Human Microvascular Endothelial Cells. Biochim Biophys Acta 1745(3):300-9.
  57. Reynolds P.R., M.L. Mucenski, T.D. LeCras, W. C. Nichols and J.A. Whitsett. 2004. Midkine (MK) induces myocardin during hypoxia and causes pulmonary vascular remodeling. J Biol. Chem. 279(35):37124-32.
  58. Reynolds P.R., M.L. Mucenski, and J.A. Whitsett. 2003. Thyroid Transcription Factor (TTF)-1 Regulates the expression of Midkine (MK) During Lung Morphogenesis. Dev. Dyn. 227:227-237.
  59. Reynolds P.R., G.B. Schaalje, and R.E. Seegmiller. 2003. Combination Therapy with Folic Acid and Methionine in the Prevention of Retinoic Acid-Induced Cleft Palate in Mice. BDRA 67:168-173.
  60. Hansen, J.M., P.R. Reynolds, G.W. Booth, G.B. Schaalje, and R.E. Seegmiller. 2000. Developmental Toxicity of Carbon Black Oil in Mice. Teratology 62:227-232.

Abstracts Presented at National or International Meetings

Undergraduate co-authors are italicized

  1. Reynolds, PR. 2018. RAGE and SAGE: Therapeutic Modalities for Smoke-Inducted COPD. Oral Presentation. Proc Physiol Soc 41 (2019).
  2. Reynolds PR. 2018. Correlation between DNA double strand break repair and RAGE in pathological placentas. Placenta J 69; e1.
  3. Hall PD, Caskey B, Hirschi K, Reynolds PR, and Arroyo JA. 2018. Gas6/AXL modulates increased inflammatory cytokines during preeclampsia in rats. EB Poster Presentation.
  4. Hirschi K, Egbert K, Clark C, Mella N, Plothow E, Mejia J, Arroyo, and Reynolds PR. 2018. Antenatal exposure to secondhand smoke impacts growth and cardiopulmonary energetics in 4-week-old mice. EB Oral Presentation.
  5. Price K, Kimbler B, Knowlton N, Franson L, Hirschi K, Reynolds PR, and Arroyo JA. 2018. Differential expression of mTOR related molecules in the placenta of gestational diabetes mellitus (GDM), intrauterine growth restriction (IUGR) and preeclampsia patients. EB Poster and Oral Presentations.
  6. Mejia JF, Hall P, Hirschi K, Reynolds PR, and Arroyo JA. 2018. Regulation of trophoblast invasion by pyruvate kinase isozyme M2 (PKM2). EB Poster Presentation.
  7. Ostergar A, Egbert K, Clark C, Hall P, Davis T, Hirschi K, Arroyo JA, and Reynolds PR. 2018. Semi-synthetic glycosaminoglycan ethers decrease receptors for advanced glycation end-products and increase AXL receptors in the lungs from secondhand smoke treated mice. EB Oral Presentation.
  8. Jacobsen JL, Dalanhese DL, Peterson M, Sarva S, Chapman S, Mejia J, Bikman BT, Reynolds PR, and Arroyo JA. 2018. Reduction of CSE-induced Ca9-22 cell invasion by SAGEs. AADR Oral Presentation.
  9. Peterson M, Sarva S, Jacobsen CL, Dalanhese DL, Hirschi KM, Chapman S, Hall P, Bikman BT, Reynolds PR, and Arroyo JA. 2018. Decreased inflammatory cytokines during Gas6-mediated invasion of gingival cells. AADR Oral presentation.
  10. Reynolds PR. 2017. Over-Expression of Receptors for Advanced Glycation End-Products (RAGE) Causes Anomalous Epithelial Cell Survival and Differentiation in the Embryonic Murine Lung. International Society for Developmental; Biologists Congress. Singapore.
  11. Whisenant EC, Wase BA, Nguyen MA,Mejia C,Wilcox SH, ReynoldsPRand Arroyo JA. 2017. Gas6Increases Invasion of Ca9-22 Gingival Cancer Cells. AADR poster.
  12. Wase BA, Nguyen MA, Whisenant EC, Mejia C, Wilcox SH, ReynoldsPRand Arroyo JA. 2017. Inhibition of AXL Receptors Decreases Invasion of Ca9-22 Cells. AADR poster.
  13. Sue S, Mick M, ReynoldsPR, Mejia C, Wilcox SH and Arroyo JA. 2017. Semi-Synthetic Glycoaminoglycan Ethers Inhibit Ca9-22 Cell Invasion Induced by CSE. AADR poster.
  14. Mick M, Sue S, Mejia C, Wilcox SH, ReynoldsPRand Arroyo JA. 2017. Cigarette Smoke Extract Increases Invasion in Ca9-22 Gingival Cancer Cells. AADR oral.
  15. Dalanhese DL, Roberts D, Vanmali SN, Peterson M, Jacobsen CL, Sarva S, Hirschi KM, Lewis JB, Wilcox SH, Winden DR, Bikman BT, Arroyo JA and ReynoldsPR. 2017. Gingival cells exposed to e-cigarette liquid induce pro-inflammatory cytokine elaboration. AADR poster.
  16. Sarva S, Vanmali SN, Dalanhese DL, Peterson M, Jacobsen CL, Hirschi KM, Lewis JB, Wilcox SH, Winden DR, Bikman BT, Arroyo JA and ReynoldsPR. 2017. Gingival cells exposed to e-cigarette liquid express differential recognition receptors. AADR oral.
  17. Jacobsen CL, Peterson M, Dalanhese DL, Roberts D, Vanmali SN, Sarva S, Witt JE, Wilcox SH, Winden DR, Bikman BT and ReynoldsPR. 2017. Gingival cell mitochondrial bioenergetics are altered with e-cigarette liquid exposure. AADR poster.
  18. Hirschi KM, Lewis JB, Hall PD, Wright TJ, Egbert KM, Ogden KC, Nelson SM, Clark JC, Milner DC, Arroyo JA, and ReynoldsPR. 2017. Abrogation of RAGE signaling using semi-synthetic glycosaminoglycan ethers (SAGEs) ameliorates inflammation in mice exposed to secondhand tobacco smoke. EB poster.
  19. Dunaway TM, Lewis JB, Hirschi KM, Mejia CA, Mejia CF, Hall PD, ReynoldsPR, Arroyo JA. 2017. Activation of AXL Receptor via Gas6 induces Preeclampsia in Rats. EB poster.
  20. Lewis JB, Mejia CA, Jordan C, Monson TD, Bodine JS, Dunaway TM, Egbert KM, Wright TJ,Ogden KC, Broberg DS, Hall PD, Nelson SM, Hirschi KM, ReynoldsPRand Arroyo JA. 2017. Inhibition of the Receptor for Advanced Glycation End-products (RAGE) protects from secondhand smoke (SHS) induced intrauterine growth restriction (IUGR) in mice. EB poster.
  21. Hirschi KM, Lewis JB, Ostergar AS,Hall PD, Broberg DS, Arroyo JA, and ReynoldsPR. 2017. Involvement of RAGE signaling and inflammatory cytokine elaboration following in vitro exposure to electronic cigarette liquid. EB poster.
  22. Mejia CA, Appiah MM, Lewis JB, Bikman BT, Hansen JM, ReynoldsPR, and Arroyo JA. 2017. Gas6 reduces cellular respiration and increases reactive oxygen species in immortalized human first trimester trophoblast cells. EB poster.
  23. Cho J, Kim JS, Lewis JB, ReynoldsPR, Bikman BT and Symons JD. 2017. Nasal Administration of Diesel Exhaust Particles Does Not Evoke Dysfunction or Initiate Autophagy in Murine Femoral Arteries. EB poster.
  24. Mejia C, Lewis JB, Mayment M, Monson T, Reynolds PR and Arroyo JA. 2016. Growth arrest-specific 6 (Gas6)/AXL signalling induces preeclampsia. Placenta 45:119.
  25. Bodine JS, Gassman JR, Muñoz SA, Milner DC, Lewis AL, Dunaway TM, Egbert KM, Christiansen CE, Christiansen AR, Monson TD, Broberg DS, Arroyo JA, and Reynolds PR. 2016. Transgenic Up-Regulation of Claudin-6 Decreases Diesel Particulate Matter (DPM)-Induced Pulmonary Inflammation. FASEB J 30:305.11.
  26. Lewis JB, Bodine JS, Milner DC, Lewis AL, Dunaway TM, Egbert KM, Albright SC, Merrill BJ, Monson TD, Watson MS, Burstedt ND, Smith QK, Gassman JR, Jergenson TR, Chavarria B, Broberg DS, Muñoz SA, Thomas DB, Arroyo JA, and Reynolds PR. 2016. Altered Inflammatory Responses In Tobacco Smoke-Exposed Mice That Over-Express The Tight Junctional Protein Claudin-6. FASEB J 30:305.12.
  27. Mejia CA, Reynolds PR, and Arroyo JA. 2016. Placental expression of NFAT5, SLC5A3, and aldose reductase in gestational diabetes mellitus. FASEB J 30:851.5.
  28. Jordan CJ, Lewis JB, Bodine JS, Lewis AL, Dunaway TM, Egbert KM, Monson TD, Ogden KC, Wright TJ, Mejia CA, Reynolds PR and Arroyo JA. 2016. Receptors for Advanced Glycation End-products (RAGE) inhibition protects form Intrauterine Growth Restriction (IUGR) during Second Hand Smoke (SHS) in Mice. FASEB J 30:1033.4.
  29. Gassman JR, Lewis JB, Milner DC, Lewis AL, Bodine JS, Dunaway TM, Monson TD, Broberg DS, Arroyo JA, and Reynolds PR. 2016. Spatial expression of Receptor for Advanced Glycation End-Products (RAGE) in diverse tissue and organ systems differs following exposure to secondhand cigarette smoke. FASEB J 30:lb741.
  30. Milner DC, Lewis JB, Winden DR, Gassman JR, Monson TD, Broberg DS, Muñoz SA, Ehrhardt C, Arroyo JA and Reynolds PR. 2016. Organic Cation Transporter Novel Type-1 (OCTN-1) And Pulmonary Responses to Secondhand Tobacco Smoke (SHS). FASEB J 30:50.4.
  31. Mejia CA, Monson TD, Jordan CJ, Bikman BT, Reynolds PR, and Arroyo JA. 2016. Treatment with diet or insulin induces a different placental Ceramide expression during gestational diabetes mellitus (GDM). FASEB J 30:851.6.
  32. Ehrhardt C, Selo MA, Clerkin CG, Talbot BN, Walsh JJ, Nakamichi N, Kato Y, Lewis JB, Reynolds PR, and Nikel S. 2016. Protective role of ergothioneine from tobacco smoke-induced oxidative stress in vitro and in vivo. FASEB J 30:982.1
  33. Napa K, Baeder AC, Richardson ST, Taylor OJ, Anderson SG, Wilcox SH, Winden DR, Reynolds PR, and Bikman BT. 2016. Gingival cells exposed to cigarette smoke extract induce muscle cell metabolic disruption. Presented at the American Association of Dental Research Annual Meeting. Los Angeles, CA, Mar 16-19, 2016.
  34. Laub SG, Taylor OJ, Reynolds PR, and Bikman BT. 2016. Gingival cell smoke exposure disrupts skeletal muscle metabolic function. FASEB J 30:920.8.
  35. Oliver OJ, Porter ME, Reynolds PR, and Bikman BT. 2016. HMGB1 mediates sidestream smoke-induced metabolic disruption. FASEB J 30:734.4.
  36. Sanders NT, Dutson DJ, Durrant JW, Gollaher CJ, Lewis JB, Merrill BJ, Milner DC, Christiansen AR, Albright SC, Christiansen CE, Wilcox SH, Winden DR, Bikman BT, and Reynolds PR. 2016. Gingival epithelial cells exposed to cigarette smoke extract include RAGE-mediated inflammation. Presented at the American Association of Dental Research Annual Meeting. Los Angeles, CA, Mar 16-19, 2016.
  37. Durrant JW, Gollaher CJ, Sanders NT, Dutson DJ, Lewis JB, Merrill BJ, Milner DC, Christiansen AR, Albright SC, Christiansen CE, Wilcox SH, Winden DR, Bikman BT, and Reynolds PR. 2016. Availability of TNF-alpha up-regulates inflammatory RAGE expression by gingival epithelia. Presented at the American Association of Dental Research Annual Meeting. Los Angeles, CA, Mar 16-19, 2016.
  38. Lewis JB, Jimenez FR, Chavarria M, Gassman JR, Jergensen TR, Albright S, Morris R, Baker P, Christiansen C, Schrader T, Millner DC, Bodine JS, Arroyo JA, and Reynolds PR. Expression profile of Claudin family members in the developing lung. Dev Biology in press
  39. Reynolds PR, Alexander K, Mejia C, Mejia J, and Arroyo JA. Induction of intrauterine growth restriction (IUGR) by secondhand smoke (SHS): a role for the Receptor for Advanced Glycation End-products (RAGE) in the development of disease. SSR: http://www.ssr.org/15Schedule, http://www.ssr.org/15SciProgram.
  40. Mejia C, Johnston A, Lutz R, Arroyo JA, and Reynolds PR. Inhibition of trophoblast invasion by the growth arrest-specific 6 (Gas6) protein. FASEB J 29:684.10.
  41. Alexander K, Lewis J, Mejia M, Howell B, Reynolds PR, and Arroyo JA. Differential Placental Expression of the Receptor for Advanced Glycation End-Products (RAGE) in Normal and Complicated Pregnancies. FASEB J 29:972.2.
  42. Mika A, Reynolds PR, and Arroyo JA. Elevated Apoptosis in Ovine Intrauterine Growth Restriction (IUGR) is Associated with Increased Caspase 3 and 9 and Decreased Telomerase Activity. FASEB J 29:978.2.
  43. Lewis J, Jimenez F, Chavarria M, Gassman J, Jergensen T, Schrader T, Millner D, Bodine J, Arroyo JA, and Reynolds PR. Expression Profile of Claudin Family Members in the Developing Lung. FASEB J 29:LB747.
  44. Mejia C, Bahr B, Reynolds PR, and Arroyo JA. Nuclear and cytosolic expression of placental PKM2 in preeclampsia and intrauterine growth restriction. FASEB J 29:684.9.
  45. Long E, Pettit N, Motwani R, Reynolds PR, and Seegmiller RE. Involvement of TGF-b1 in the initial phase of TMJ and knee osteoarthritis. Arthritis and Cartilage 23:A320.
  46. Pettit N., Motwani R., Long E., Reynolds P.R. and Seegmiller R.E. 2014. Involvement of TGFB1 in the initial phase of TMJ osteoarthritis. IADR Meeting 2014.
  47. Jimenez F.R., Belgique S.T., Albright S.A., Jones C.M., and Reynolds P.R. 2014. Conditional pulmonary overexpression of Claudin 6 (Cldn6) during embryogenesis delays lung morphogenesis. APS Comparative Physiology Conference 2014.
  48. Tippetts T., Winden D.R., Wagner M., Condie T., Reynolds P.R., and Bikman B. 2014. Ceramide is necessary for cigarette smoke-induced reduced heart mitochondrial function. ADA Meeting 2014. Diabetes 63(S1): 1855-P, A447.
  49. Nelson M.B., Tippetts T., Winden D.R., Reynolds P.R., and Bikman B. 2014. RAGE activation reduces cardiomyocyte mitochondrial function in a ceramide-dependent manner. ADA Meeting 2014. Diabetes 63(S1): 447-P, A117.
  50. Thatcher M., Tippetts T., Johnson I., Holub Z., Nelson M., Winden D.R., Reynolds P.R., and Bikman B. 2014. Ceramide mediates cigarette smoke-induced skeletal muscle metabolic disruption. ADA Meeting 2014. Diabetes 63(S1): 1854-P, A447.
  51. Wilhelm S., Mecham D., Chavez E.M., Kartchner J., Crepeau P., Anderson K., Vandruff J., Robinson M., Christensen I., Taylor K., Reynolds P, and Kooyman D. 2014. Blocking of the receptor for advanced glycation end-products but not Toll-like receptor 4 attenuates the progression of OA. FASEB J 28:835.13.
  52. Chavez C.M., Mecham D., Wilhelm S., Black C., Mitchell J., Anderson K., Graf J., Macdonald J., Reynolds P., and Kooyman D. 2014. Knocking out RAGE disrupts natural repair of condylar cartilage during osteoarthritis. FASEB J 28:835.14.
  53. Jimenez F.R., Lewis J.B., Belgique S.T., Wood T.T. and Reynolds P.R. 2014. Pulmonary expression and regulation of Cldn6 by tobacco smoke. FASEB J 28:834.3
  54. Wood T.T., Winden D.R., Barton D.B., Betteridge B.C., Marlor D.R., Wright A.J., Jones C.M., Chavarria M., Rogers G.D., and Reynolds P.R. 2014. Targeted mice reveal a role for RAGE in an early inflammatory response to tobacco smoke. FASEB J 28:834.4.
  55. Reynolds, P.R. 2013. Characterization of a new mouse model of COPD via conditional over-expression of RAGE by alveolar epithelium. Proc Phys Soc, Proc 37th IUPS, PCD055.
  56. Thacher M.O., Brassfield E.S., Smith M.E., Nelson M.B., Reynolds P.R. and Bikman B.T. 2013. Smoking mediates smoking-induced insulin resistance. FASEB J 27:874.27.
  57. Wilhelm S.K., Doxey A.S., Karchner J.Z., Vernderuff J., Anderson K., Draper C.S., Chavez E., Reynolds P.R., and Kooyman D.L. 2013 Apoptosis associated with osteoarthritis is attenuated in mice lacking receptor for advanced glycation end products (RAGE). FASEB J 27:573.5.
  58. Larkin J.D., Kartchner J.Z., Doxey A.S., Rees J.L., Hollis W.R., Wilhelm S.K., Peterson D.M., Jackson G.G., Haynie S.S., Draper C.S., Chavez E., Reynolds P.R., and Kooyman D.L. 2013. Inflammatory markers associated with osteoarthritis after destabilization surgery in mice with and without Receptor for Advanced Glycation End Products (RAGE). FASEB J 27:573.3.
  59. Jimenez F.R., Lewis J.B., Wood T.T., and Reynolds P.R. 2013. Developmental expression and transcriptional regulation of claudin-6 in the murine lung. FASEB J 27:256.4.
  60. Bennion B.G., Bodine B.G., Leatham E., Wright A.J., Jergensen Z.R., Erickson C.J., Jones C.M., Johnson J.P., Knapp S.M., and Reynolds P.R. 2013. Over-expression of RAGE by proximal lung epithelial cells causes an inflammatory response in adult mice. FASEB J 27:137.12.
  61. Barton D.B., Betteridge B.C., Earley T.D., Robinson A.B., and Reynolds P.R. 2013. RAGE signaling influences diesel particulate matter-induced inflammation in primary alveolar macrophages. FASEB J 27:254.11.
  62. Reynolds P.R. 2012. Over-Expression of Receptors for Advanced Glycation End-Products (RAGE) Causes Anomalous Epithelial Cell Survival and Differentiation in the Embryonic Murine Lung. Dev Biol 368 (2012), 151.
  63. Jacobs M., Hardman S., Moore T., Lew J., Reynolds P.R., and Thomson D.M. 2012. RAGE and STAT3 signaling in chronic AICAR-treated young adult and old skeletal muscle. The Physiologist 55:6, C-56.
  64. Farmer A.W. and Reynolds P.R. 2012. Receptors for advanced glycation end-products (RAGE) are transcriptionally inhibited by FoxA2 in diverse pulmonary cell types. FASEB 26:1151.13
  65. Robinson A.B., Johnson K.D., Bennion B.G., and Reynolds P.R. 2012. RAGE signaling influences tobacco smoke-induced inflammation by pulmonary macrophages. FASEB 26:1064.10.
  66. Curtis C.S., Earley T.D., Robinson A.B., and Reynolds P.R. 2012. Diesel particulate matter (DPM) induces receptor for advanced glycation end-products (RAGE) expression by pulmonary macrophages. FASEB 26:143.1
  67. Johnson K.D., Robinson A.B., and Reynolds P.R. 2012. RAGE signaling influences smoke-induced secretion of pro-inflammatory cytokines by primary alveolar macrophages. FASEB 26:656.3
  68. Kartchner J.Z., Peterson D.M., Larkin D.J., Doxey A.S., Hollis W.R., Rees J.L., Ingersoll C., Jackson G.G., Wilhelm S.K., Haynie S.S., Seegmiller R.E., Stogsdill J.A., Reynolds P.R., and Kooyman D.L. 2012. Expression of biomarkers of osteoarthritis in mice with and without receptor for advanced glycation end products (RAGE). FASEB 26:lb139.
  69. Bukey B.R., Porter J.L., Hancock J.M., Stogsdill J.A., and Reynolds P.P. 2012. Increased MMP-9 activity in mice that over-express RAGE in alveolar epithelium destabilizes the basement membrane by degrading collagen type IV. Dev Biol 356 (1), 143-44.
  70. Geyer A.J., Ferguson N.T. and Reynolds P.R. 2012. Conditional embryonic over-expression of RAGE in the mouse lung diminishes pulmonary endothelium expression. Dev Biol 356 (1), 143-44.
  71. Porter J.L., Bukey B.R., Geyer A. J. and Reynolds P.R. 2011. Temporal-Spatial Expression of Alpha 5 Nicotinic Acetylcholine Receptor (nAChR) Subunits During Mouse Lung Organogenesis. FASEB J 25:660.1.
  72. Stogsdill J.A., Stogsdill M.P., and Reynolds P.R. 2011. Embryonic over-expression of RAGE in mouse lung causes an imbalance between apoptosis and proliferation leading to severe lung hypoplasia. FASEB J 25:660.6
  73. Stogsdill M.P., Stogsdill J.A., Porter J.L., Bodine G. and Reynolds P.R. 2011. Persistent over-expression of RAGE in adult mouse lung causes airspace enlargement coincident with emphysema FASEB J 25:114.6.
  74. Fredrickson A.C., Sefcik T.L., and Reynolds P.R. 2011. A new RAGE blocker, low anti-coagulant 2-O,3-O desulfated heparin (ODSH), diminishes smoke-induced pulmonary inflammation. FASEB J 25:114.5.
  75. Willnauer, C.P. and Reynolds P.R. 2010. TTF-1 Transcriptionally Regulates a5 nAChRs in Subsets of Proximal and Distal Lung Epithelial Cells. FASEB J 24:798:1.
  76. Wasley K.M., Allison C.H., and Reynolds P.R. 2010. Diesel Particulate Matter Induces Receptor for Advanced Glycation End-Products (RAGE) Expression in Alveolar Epithelial Cells and Mediates an Inflammatory Response. FASEB J 24:612:20.
  77. Stogsdill J.A., Phinney M.N., and Reynolds P.R. 2010. Conditional up-regulation of Receptors for Advanced Glycation End-Products (RAGE) in Alveolar Epithelium Causes Respiratory Distress and Perinatal Lethality. FASEB J 24:798:4.
  78. Willnauer, C.P., Allison C.H., and Reynolds P.R. 2009. TTF-1 and Egr-1 Differentially Regulate a5 nAChRs in Proximal Lung Epithelium During Lung Development. Mech. Dev. 126:S214.
  79. Schmitt R.E., Reynolds P.R., Kasteler S.D., and Hoidal J.R. 2009. The receptor for advanced glycation end products (RAGE) activates Ras and NFκ-β in pulmonary epithelial cells exposed to cigarette smoke. (ATS)
  80. Kasteler S.D., Reynolds P.R., and Hoidal J.R. 2008. Downstream effects of receptors for advanced glycation end products (RAGE) in pulmonary epithelial cells exposed to cigarette smoke. PATS 177:A333.
  81. Reynolds P.R., Kasteler S.D., Sturrock A., Sanders K., Kennedy T.P., and Hoidal J.R. 2008. RAGE targeting leads to protection from hyperoxia-induced lung injury. FASEB J. 22:762.2.
  82. Reynolds P.R. and Hoidal J.R. 2007. Expression and TTF-1-mediated Transcriptional Control of a5 nAChRs in the Developing Mouse Lung. Dev Biol 306:354.
  83. Reynolds P.R., Kasteller S.D., and Hoidal J.R. 2007. Cigarette smoke-mediated regulation of receptors for advanced glycation end products by Egr-1. PATS 175:A257.
  84. Reynolds, P.R., T.P. Huecksteadt , A. Sturrock, and J.R. Hoidal. 2006. Developmental expression and regulation of receptors for advanced glycation end products (RAGE). 2006 Dev Biol 295:379.
  85. Reynolds P.R. and J.R. Hoidal. 2005. Pulmonary Expression and Transcriptional Regulation of a7 Nicotinic Acetylcholine Receptors by TTF-1 and Egr-1 During Development. Dev Biol 283(2):605.
  86. Reynolds P.R. and J.R. Hoidal. 2005. Temporal-Spatial Expression and Transcriptional Regulation of a7 Nicotinic Acetylcholine Receptor (nAChR) During Murine Lung Development. PATS 2:A467.
  87. Reynolds P.R., M.L. Mucenski, and J.A. Whitsett. 2004. Midkine (MK) Causes Pulmonary Vascular Remoeling and is Responsive to Hypoxia Via HIF-1a. Cardiovascular Pathology 13 (3S): S15
  88. Reynolds P.R., M.L. Mucenski, and J.A. Whitsett. 2003. Immunolocalization and Transcriptional Regulation of Midkine (MK) in Developing Mouse Lung. Am. J. Resp. Crit. Care Med. 167(7):A377.
  89. Reynolds P.R., G.B. Schaalje, and R.E. Seegmiller. 2001. Retinoic Acid-induced Cleft Palate in Mice by Separate and Concomitant Administration of Folate and Methionine. Teratology 63(6):245.
  90. Fillmore A.D., P.R. Reynolds, D. Griner, C.L. Fillmore, J.M. Dunn, A.K. Syphus, M.S. Hale, G.B. Schaalje, and R.E. Seegmiller. 2002. Rescue of Retinoic Acid-Induced Cleft Palate in Mice by Oral Administration of Folic Acid. Teratology 65(6):335.