Lab Research
Research
The following are proposed pathways for OA being investigated in the Kooyman Lab.
The upper schematic summarizes the proposed HtrA1-Ddr2-MMP13 mechanism of cartilage degradation in collagen mutant models of OA. If the risk factors or initiating causes of OA each activate a separate pathway, the problem regarding treatment is magnified, whereas if all or most initiating causes activate a common molecular pathway, the problem regarding therapy is simplified as shown in the lower diagram.
![](https://brightspotcdn.byu.edu/dims4/default/374ed58/2147483647/strip/true/crop/583x581+0+0/resize/583x581!/quality/90/?url=https%3A%2F%2Fbrigham-young-brightspot.s3.amazonaws.com%2Fa4%2F5a%2F53c961b649ddada8ecdefd63999b%2Fkooyman.jpg)
![](https://brightspotcdn.byu.edu/dims4/default/041b351/2147483647/strip/true/crop/605x323+0+0/resize/605x323!/quality/90/?url=https%3A%2F%2Fbrigham-young-brightspot.s3.amazonaws.com%2F8e%2F04%2Fb0bc447646b69586007860f38b29%2Fkooyman2.jpg)