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Journal Articles

Ross MM, Piorczynski TB, Harvey J, Burnham TS, Francis M, Larson MW, Roe K, Hansen JM, Stark MR. 2019. Ceramide: a novel inducer for neural tube defects. Developmental Dynamics. 219:979-996.

Mackay AD, Marchant ED, Munk DJ, Watt RK, Hansen JM, Thomson DM, Hancock CR. 2019. Multi-Tissue Analysis of Exercise or Metformin on Doxorubicin-Induced Iron Dysregulation. doi:10.1152/ajpendo.00140.2018

Rowley, 4th TJ, Bitner BF, Ray JD, Lathen DR, Smithson AT, Dallon BW, Plowman CJ, Bikman BT, Hansen JM, Dorenkott MR, et al. 2017. Monomeric cocoa catechins enhance β-cell function by increasing mitochondrial respiration. 49:30-41. doi:10.1016/j.jnutbio.2017.07.015

Chen T, Moore TM, Ebbert MT, McVey NL, Madsen SR, Hallowell DM, Harris AM, Mackay RP, Char RE, Hancock CR, et al. 2016. Liver kinase B1 inhibits the expression of inflammation-related genes post-contraction in skeletal muscle. Journal of applied physiology. 120(8):876-888.

Harris C, Jilek JL, Sant KE, Pohl J, Reed M, Hansen JM. 2015. Amino acid starvation induced by protease inhibition produces differential alterations in redox status and the thiol proteome in organogenesis-stage rat embryos and visceral yolk sacs. The Journal of nutritional biochemistry. 26(12):1589-98. doi:10.1016/j.jnutbio.2015.07.026

Jilek JL, Sant KE, Cho KH, Reed MS, Pohl J, Hansen JM, Harris C. 2015. Ethanol Attenuates Histiotrophic Nutrition Pathways and Alters the Intracellular Redox Environment and Thiol Proteome during Rat Organogenesis. Toxicological Sciences. 147(2):475-89. doi:10.1093/toxsci/kfv145

Hansen JM, Harris C. 2015. Glutathione during embryonic development. Biochimica et biophysica acta. 1850(8):1527-42. doi:10.1016/j.bbagen.2014.12.001

Easley, 4th CA, Bradner JM, Moser A, Rickman CA, McEachin ZT, Merritt MM, Hansen JM, Caudle WM. 2015. Assessing reproductive toxicity of two environmental toxicants with a novel in vitro human spermatogenic model. Stem cell research. 14(3):347-55. doi:10.1016/j.scr.2015.03.002

Downs CA, Kreiner L, Zhao XM, Trac P, Johnson NM, Hansen JM, Brown LA, Helms MN. 2015. Oxidized glutathione (GSSG) inhibits epithelial sodium channel activity in primary alveolar epithelial cells. American journal of physiology. Lung cellular and molecular physiology. 308(9):L943-52. doi:10.1152/ajplung.00213.2014

Hunt WR, Zughaier SM, Guentert DE, Shenep MA, Koval M, McCarty NA, Hansen JM. 2014. Hyperglycemia impedes lung bacterial clearance in a murine model of cystic fibrosis-related diabetes. American journal of physiology. Lung cellular and molecular physiology. 306(1):L43-9. doi:10.1152/ajplung.00224.2013

Timme-Laragy AR, Goldstone JV, Imhoff BR, Stegeman JJ, Hahn ME, Hansen JM. 2013. Glutathione redox dynamics and expression of glutathione-related genes in the developing embryo. Free radical biology & medicine. 65:89-101. doi:10.1016/j.freeradbiomed.2013.06.011

Harris CW, Shuster DZ, Roman Gomez R, Sant KE, Pohl J, Hansen JM. 2013. Inhibition of glutathione biosynthesis alters compartmental redox status and the thiol proteome in organogenesis-stage rat conceptuses. Free radical biology & medicine. 63:325-37. doi:10.1016/j.freeradbiomed.2013.05.040

Kathiria AS, Butcher MA, Hansen JM, Theiss AL. 2013. Nrf2 is not required for epithelial prohibitin-dependent attenuation of experimental colitis. American journal of physiology. Gastrointestinal and liver physiology. 304(10):G885-96. doi:10.1152/ajpgi.00327.2012

Hansen JM, Harris C. 2013. Redox control of teratogenesis. Reproductive toxicology. 35:165-79. doi:10.1016/j.reprotox.2012.09.004

Siore AM, Parker RE, Cuppels C, Thorn N, Hansen JM, Stecenko AA, Brigham KL. 2012. The role of mitochondrial oxidation in endotoxin-induced liver-dependent swine pulmonary edema. Pulmonary pharmacology & therapeutics. 25(5):407-12. doi:10.1016/j.pupt.2012.08.002

Harris C, Hansen JM. 2012. Nrf2-mediated resistance to oxidant-induced redox disruption in embryos. Birth defects research. Part B, Developmental and reproductive toxicology. 95(3):213-8. doi:10.1002/bdrb.21005

Hansen JM. 2012. In vivo models of developmental toxicology. Methods in molecular biology. 889:7-13. doi:10.1007/978-1-61779-867-2_2

Harris C, Hansen JM. 2012. Oxidative stress, thiols, and redox profiles. Methods in molecular biology. 889:325-46. doi:10.1007/978-1-61779-867-2_21

Hansen JM. 2012. Thioredoxin redox status assessment during embryonic development: the redox Western. Methods in molecular biology. 889:305-13. doi:10.1007/978-1-61779-867-2_19

Roede JR, Hansen JM, Go YM, Jones DP. 2011. Maneb and paraquat-mediated neurotoxicity: involvement of peroxiredoxin/thioredoxin system. Toxicological sciences. 121(2):368-75. doi:10.1093/toxsci/kfr058

Imhoff BR, Hansen JM. 2011. Differential redox potential profiles during adipogenesis and osteogenesis. Cellular & molecular biology letters. 16(1):149-61. doi:10.2478/s11658-010-0042-0

Wu J, Hansen JM, Hao L, Taylor RN, Sidell N. 2011. Retinoic acid stimulation of VEGF secretion from human endometrial stromal cells is mediated by production of reactive oxygen species. The Journal of physiology. 589(Pt 4):863-75. doi:10.1113/jphysiol.2010.200808

Fischer L, Igoudjil A, Magrané J, Li Y, Hansen JM, Manfredi G, Glass JD. 2011. SOD1 targeted to the mitochondrial intermembrane space prevents motor neuropathy in the Sod1 knockout mouse. Brain. 134(Pt 1):196-209. doi:10.1093/brain/awq314

Imhoff BR, Hansen JM. 2010. Tert-butylhydroquinone induces mitochondrial oxidative stress causing Nrf2 activation. Cell biology and toxicology. 26(6):541-51. doi:10.1007/s10565-010-9162-6

Imhoff BR, Hansen JM. 2010. Extracellular redox environments regulate adipocyte differentiation. Differentiation. 80(1):31-9. doi:10.1016/j.diff.2010.04.005

Imhoff BR, Hansen JM. 2009. Extracellular redox status regulates Nrf2 activation through mitochondrial reactive oxygen species. The Biochemical journal. 424(3):491-500. doi:10.1042/BJ20091286

Tipple TE, Welty SE, Nelin LD, Hansen JM, Rogers L. 2009. Alterations of the thioredoxin system by hyperoxia: implications for alveolar development. American journal of respiratory cell and molecular biology. 41(5):612-9. doi:10.1165/rcmb.2008-0224OC

Kleinhenz JM, Kleinhenz DJ, You S, Ritzenthaler JD, Hansen JM, Archer DR, Sutliff RL, Hart M. 2009. Disruption of endothelial peroxisome proliferator-activated receptor-gamma reduces vascular nitric oxide production. American journal of physiology. Heart and circulatory physiology. 297(5):H1647-54. doi:10.1152/ajpheart.00148.2009

Lin PW, Myers LE, Ray L, Song SC, Nasr TR, Berardinelli AJ, Kundu K, Murthy N, Hansen JM, Neish AS. 2009. Lactobacillus rhamnosus blocks inflammatory signaling in vivo via reactive oxygen species generation. Free radical biology & medicine. 47(8):1205-11. doi:10.1016/j.freeradbiomed.2009.07.033

Widder JD, Fraccarollo D, Galuppo P, Hansen JM, Jones D, Ertl G, Bauersachs J. 2009. Attenuation of angiotensin II-induced vascular dysfunction and hypertension by overexpression of Thioredoxin 2. Hypertension. 54(2):338-44. doi:10.1161/HYPERTENSIONAHA.108.127928

Theiss AL, Vijay-Kumar M, Obertone TS, Jones D, Hansen JM, Gewirtz AT, Merlin D, Sitaraman SV. 2009. Prohibitin is a novel regulator of antioxidant response that attenuates colonic inflammation in mice. Gastroenterology. 137(1):199-208, 208.e1-6. doi:10.1053/j.gastro.2009.03.033

Gletsu-Miller N, Hansen JM, Jones D, Go YM, Torres WE, Ziegler TR, Lin E. 2009. Loss of total and visceral adipose tissue mass predicts decreases in oxidative stress after weight-loss surgery. Obesity (Silver Spring, Md.). 17(3):439-46. doi:10.1038/oby.2008.542

Lewis JP, Messer RL, Pitts L, Hsu SD, Hansen JM, Wataha JC. 2009. Ni(II) ions dysregulate cytokine secretion from human monocytes. Journal of biomedical materials research. Part B, Applied biomaterials. 88(2):358-65. doi:10.1002/jbm.b.31063

Wataha JC, Lewis J, McCloud VV, Shaw M, Omata Y, Lockwood PE, Messer RL, Hansen JM. 2008. Effect of mercury(II) on Nrf2, thioredoxin reductase-1 and thioredoxin-1 in human monocytes. Dental materials. 24(6):765-72. doi:10.1016/

Hansen JM, Moriarty-Craige S, Jones D. 2007. Nuclear and cytoplasmic peroxiredoxin-1 differentially regulate NF-kappaB activities. Free radical biology & medicine. 43(2):282-8. doi:10.1016/j.freeradbiomed.2007.04.029

Halvey PJ, Hansen JM, Johnson JM, Go YM, Samali A, Jones D. 2007. Selective oxidative stress in cell nuclei by nuclear-targeted D-amino acid oxidase. Antioxidants & redox signaling. 9(7):807-16. doi:10.1089/ars.2007.1526

Hansen JM, Klass M, Harris C, Csete M. 2007. A reducing redox environment promotes C2C12 myogenesis: implications for regeneration in aged muscle. Cell biology international. 31(6):546-53. doi:10.1016/j.cellbi.2006.11.027

Go YM, Ziegler TR, Johnson JM, Gu L, Hansen JM, Jones D. 2007. Selective protection of nuclear thioredoxin-1 and glutathione redox systems against oxidation during glucose and glutamine deficiency in human colonic epithelial cells. Free radical biology & medicine. 42(3):363-70. doi:10.1016/j.freeradbiomed.2006.11.005

Ramachandiran S, Hansen JM, Jones D, Richardson J, Miller GW. 2007. Divergent mechanisms of paraquat, MPP+, and rotenone toxicity: oxidation of thioredoxin and caspase-3 activation. Toxicological sciences. 95(1):163-71. doi:10.1093/toxsci/kfl125

Hansen JM. 2006. Oxidative stress as a mechanism of teratogenesis. Birth defects research. Part C, Embryo today : reviews. 78(4):293-307. doi:10.1002/bdrc.20085

Hansen JM, Zhang H, Jones D. 2006. Mitochondrial thioredoxin-2 has a key role in determining tumor necrosis factor-alpha-induced reactive oxygen species generation, NF-kappaB activation, and apoptosis. Toxicological sciences. 91(2):643-50. doi:10.1093/toxsci/kfj175

Hansen JM, Zhang H, Jones D. 2006. Differential oxidation of thioredoxin-1, thioredoxin-2, and glutathione by metal ions. Free radical biology & medicine. 40(1):138-45. doi:10.1016/j.freeradbiomed.2005.09.023

Hansen JM, Go YM, Jones D. 2006. Nuclear and mitochondrial compartmentation of oxidative stress and redox signaling. Annual review of pharmacology and toxicology. 46:215-34. doi:10.1146/annurev.pharmtox.46.120604.141122

Hansen JM, Watson WH, Jones D. 2004. Compartmentation of Nrf-2 redox control: regulation of cytoplasmic activation by glutathione and DNA binding by thioredoxin-1. Toxicological sciences. 82(1):308-17. doi:10.1093/toxsci/kfh231

Hansen JM, Gong SG, Philbert M, Harris C. 2002. Misregulation of gene expression in the redox-sensitive NF-kappab-dependent limb outgrowth pathway by thalidomide. Developmental dynamics. 225(2):186-94. doi:10.1002/dvdy.10150

Hansen JM, Harris KK, Philbert MA, Harris C. 2002. Thalidomide modulates nuclear redox status and preferentially depletes glutathione in rabbit limb versus rat limb. The Journal of pharmacology and experimental therapeutics. 300(3):768-76.

Hansen JM, Carney EW, Harris C. 1999. Differential alteration by thalidomide of the glutathione content of rat vs. rabbit conceptuses in vitro. Reproductive toxicology. 13(6):547-54.

Book Chapter

Hansen JM, Plowman CJ, Piorczynski TB. 2017. Developmental toxicity of antiepileptic drugs-- An update. , editor. Comprehensive Toxciology.


Hansen JM, Harris C. 2004. A novel hypothesis for thalidomide-induced limb teratogenesis: redox misregulation of the NF-kappaB pathway. 1st ed. doi:10.1089/152308604771978291


Hansen JM, Char RE, Crofts B, Harris C. Dysregulation of the redox proteome in teratogenesis: Mediation throught Nrf2 activation. Teratology Society. 2015 .

Hansen JM. Inhibition of valproic acid-induced malformation through Nrf2 activation. Teratology Society Annual Meetings. 2014 .